Select one of the drugs presented from this week’s reading assignment and lecture (Week Three). Describe how the drug is used in the patient population you care for.
What is the mechanism of action of the drug you selected?
Describe how you would monitor for effectiveness and potential side effects of this drug.
Have you cared for any patients who have had an adverse event from this medication? If so, briefly describe the adverse event and the treatment required to correct or prevent further complications.
Do not include any patient identifying information or facility information in your post. All posts must include reference citation in APA format. You may use course materials, course textbook, journal articles, or peer reviewed online resources such as Medscape, Centers for Disease Control, American College of Cardiology, American Nurses Association, etc. as references for your posts. Use Heparin
Heparin is a drug that occurs in the group of endogenous glycosaminoglycans (GAGS) and it has the highest charge density (Liang & Piyathilake, 2012). The patient population under my care comprise of individuals with burns and heparin has been my drug of choice in the management this condition. Worldwide, burns require high standard attention due to its high mortality and morbidity rates (Chandra, 2016). The first step in treatment involves the classification of burns as either 1st degree or 2nd degree. The 1st-degree burns are as a result of fire while the 2nd-degree burns are more intensive and occur typically as a result of chemical or electric burns (Smythe et al., 2016). The administration of heparin involves leaving the wound exposed for some time and thereafter receiving 20000UI of heparin three times a day for each of the 0.5% affected surface. Heparin can be in various classes: anticoagulants, hematologic and cardiovascular (Heparin dosing, 2019). Mechanism of action of heparin involves inhibiting thrombin and Factor X within the coagulation cascade (Heparin – American College of Cardiology, 2019). The drug heparin thus works directly in treating wounds without involving the antithrombin as a mediator.
In evaluating the effectiveness of heparin, it should enhance healing of the burns and consequent wounds without clot formation and coagulation of blood. Side effects of heparin will be indicated by spontaneous bleeding, neurovascular symptoms, and dehydration due to excess excretion of sodium (Liang & Piyathilake, 2012). Some of my patients have had some of these adverse effects of heparin administration. For instance, one of my patients suffered excessive bleeding after being administered with heparin. This was a result of heparin inhibiting activities of antithrombin III thereby interfering with clotting process by prothrombin not being converted to thrombin and fibrinogen, not to fibrin. This can be reversed by administering protamine sulfate which reduces bleeding by binding heparin ions thereby inhibiting anticoagulant activity.
Chandra, S. (2016). Management of burns by conventional & topical heparin: A comparative study. Journal of Advanced Medical and Dental Sciences Research, 4(6), 121-124.
Heparin – American College of Cardiology. (2019). Retrieved from https://www.acc.org/tools-and-practice-support/clinical-toolkits/atrial-fibrillation-afib/anticoagulant-dosing-table/heparin
Heparin dosing, indications, interactions, adverse effects, and more. (2019). Retrieved from https://reference.medscape.com/drug/calciparine-monoparin-heparin-342169
Liang, R., & Piyathilake, D. E. (2012). Heparin : Properties, uses, and side effects. [Hauppauge] N.Y.]: Nova Science Publishers, Inc. Retrieved from http://vlib.excelsior.edu/login?url=https://search.ebscohost.com/login.aspx?direct=true&db=nlebk&AN=581837&site=eds-live&scope=site
Smythe, M. A., Priziola, J., Dobesh, P. P., Wirth, D., Cuker, A., & Wittkowsky, A. K. (2016). Guidance for the practical management of the heparin anticoagulants in the treatment of venous thromboembolism. Journal of Thrombosis and Thrombolysis, 41(1), 165-186.